biological activity | Bis-PEG9-NHS ester is a PROTAC connection bridge, belonging to PEG class and Alkyl/ether class. Bis-PEG9-NHS ester can be used to synthesize a series of PROTAC molecules. Bis-PEG9-NHS ester is a degradable (cleavable) ADC link bridge for the synthesis of antibody drug conjugates (ADCs). |
target | Cleavable PEGs Alkyl/ether |
in vitro research | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |